An Aminocatalyzed Michael Addition/Iron-Mediated Decarboxylative Cyclization Sequence for the Preparation of 2,3,4,6-Tetrasubstituted Pyridines: Scope and Mechanistic Insights
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https://figshare.com/articles/dataset/An_Aminocatalyzed_Michael_Addition_Iron-Mediated_Decarboxylative_Cyclization_Sequence_for_the_Preparation_of_2_3_4_6-Tetrasubstituted_Pyridines_Scope_and_Mechanistic_Insights/5433277
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资源简介：
A novel,
scalable strategy for the preparation of 2,3,4,6-tetrasubstituted
pyridines is described. This protocol has two steps: an aminocatalyzed
addition of ketones to alkylidene isoxazol-5-ones, followed by an
iron-mediated decarboxylative cyclization event. Mechanistic insights
for both steps are provided based on HRMS-ESI(+) studies.
创建时间：
2017-09-22
