X-ray crystal structure of Plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative
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X-ray crystal structure of Plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative Descriptor: 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Kongsaeree, P, Khongsuk, P, Leartsakulpanich, U, Chitnumsub, P, Tarnchompoo, B, Walkinshaw, M.D, Yuthavong, Y. Deposit date: 2005-03-02 Release date: 2005-09-07 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structure of Dihydrofolate Reductase from Plasmodium Vivax: Pyrimethamine Displacement Linked with Mutation-Induced Resistance. Proc.Natl.Acad.Sci.USA, 102, 2005
间日疟原虫（Plasmodium vivax）二氢叶酸还原酶（dihydrofolate reductase, DHFR）与乙胺嘧啶（pyrimethamine）及其衍生物形成复合物的X射线晶体结构
描述符：5-(4-氯苯基)-6-乙基嘧啶-2,4-二胺、二氢叶酸还原酶-胸苷酸合酶、还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）
作者：Kongsaeree, P、Khongsuk, P、Leartsakulpanich, U、Chitnumsub, P、Tarnchompoo, B、Walkinshaw, M.D、Yuthavong, Y
存档日期：2005-03-02
发布日期：2005-09-07
最后修改日期：2023-12-13
实验方法：X射线衍射法（分辨率1.9 Å）
引用文献：《间日疟原虫二氢叶酸还原酶晶体结构：乙胺嘧啶置换与突变诱导耐药性的关联》，《美国国家科学院院刊》（Proc. Natl. Acad. Sci. USA），第102卷，2005年
创建时间：
2005-03-02
