Subject baseline characteristics.

aDetermined by Cockroft formula: males = [(140 − age)×body weight]/[72×serum creatinine (mg/dL)]; females = [(140 − age)×body weight]/[72×serum creatinine (mg/dL)]×0.85.bAlthough 12 subjects had not experienced a relapse in the previous 12 months (4 in the 1000-mg bid group, 3 in each of the 100-mg bid and 500-mg bid groups, and 1 in each of the 1000-mg qd and placebo groups), they all fulfilled the inclusion criteria of having had at least one relapse in the previous 24 months.bid = twice daily; BMI = body mass index; EDSS = Expanded Disability Status Scale; qd = once daily; SD = standard deviation.