Ophthalmate biosynthesis in hepatocytes
收藏wikipathways.github.io2025-03-26 收录
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This pathway visualises the mechanism of ophthalmate biosynthesis in hepatocytes. GSH can inhibits GCC; however when the cell is facing oxidative stress, GSH is consumed, and therefore activating GCS. This enhances the biosynthesis of ophthalmate, which is transported out of the cell over the hepatocellular membrane via MRP transporters.
本路径图展示了肝细胞中视黄醇生物合成的机制。谷胱甘肽可抑制谷氨酰半胱氨酸合成酶（GCC），然而，当细胞面临氧化应激时，谷胱甘肽被消耗，从而激活谷氨酰半胱氨酸合成酶（GCS）。这促进了视黄醇的生物合成，通过MRP转运蛋白跨越肝细胞膜将视黄醇输出细胞。
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