mTopic - Supplementary h5mu data

Uploaded files are raw (*_raw.h5mu), filtered (*_filtered.h5mu), and trained (*_trained.h5mu) h5mu objects, as processed by mTopic.Single-cell data processed here are publicly available from the Gene Expression Omnibus (GEO) and 10x Genomics: P22 mouse brain datasets (P22_Mouse_Brain_ATAC_RNA, P22_Mouse_Brain_H3K4me3_RNA, P22_Mouse_Brain_H3K27me3_RNA, P22_Mouse_Brain_H3K27ac_RNA) [1] RNA data: GSE218593– GSM6753043 for ATAC-RNA– GSM6753046 for H3K4me3-RNA– GSM6753044 for H3K27me3-RNA– GSM6753045 for H3K27ac-RNA ATAC/histone modification data: GSE205055 – GSM6758285 for ATAC-RNA– GSM6704980 for H3K4me3-RNA– GSM6704978 for H3K27me3-RNA– GSM6704979 for H3K27ac-RNA Human tonsil dataset (Human_Tonsil_RNA_Protein)Available from 10x Genomics here. Human PBMC dataset (Human_PBMC_ATAC_RNA_Protein) [2]GSE166188– GSM5065524 for ATAC– GSM5065525 for RNA– GSM5065526 for protein References[1] Zhang D, Deng Y, Kukanja P, Agirre E et al. Spatial epigenome-transcriptome co-profiling of mammalian tissues. Nature 2023 Apr;616(7955):113-122. PMID: 36922587[2] Mimitou EP, Lareau CA, Chen KY, Zorzetto-Fernandes AL et al. Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells. Nat Biotechnol 2021 Oct;39(10):1246-1258. PMID: 34083792