Table 2_Susceptibility and resistance of Gram-negative bacteria to a novel antimicrobial agent TGV-49.docx

IntroductionAntimicrobial resistance remains a major global public health challenge that necessitates novel drugs with a low resistance rate. MethodsHerein, we evaluate TGV-49, a novel broad-spectrum antimicrobial agent, against multidrug-resistant Gram-negative bacteria, including ESKAPE pathogens (Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae) and pathogens from agriculture that infect humans (Ralstonia solanacearum and Aeromonas hydrophila). ResultsTGV-49 was highly effective in overcoming resistance to conventional antibiotics. The experimental evolution of A. baumannii using a morbidostat revealed minimal development of resistance. ConclusionOur findings suggest TGV-49 as a potential alternative for combating MDR infections in clinical and agricultural settings.