Data_Sheet_1_Fear of progression, loneliness, and hope in patients with gastrointestinal cancer: a cross-sectional relational study.docx

IntroductionIn recent years, fear of disease progression (FoP) has become one of the most common psychological problems in cancer patients. However, there are fewer studies on the FoP in patients with gastrointestinal tumors. We aimed to assess the level of FoP in patients with gastrointestinal tumors and analyze the factors related to FoP. We also aimed to examine the relationship among loneliness, hope and FoP in patients with gastrointestinal cancer.MethodsA cross-sectional survey was conducted on three Grade A hospitals in southwestern China from November 2021 to July 2022. The demographic and clinical characteristics questionnaire, Fear of Disease Progression Scale (FoP-Q-SF), Cancer Loneliness Scale (CLS), and Herth Hope Index (HHI) were included in this study. Data analysis included descriptive statistics, independent samples t-tests, one-way analysis of variance, and multiple linear regression analysis.ResultsIn total, 245 gastrointestinal cancer patients participated in this study. The average (standard deviation) FoP score in patients was 32.94 ± 10.64. In total, 245 gastrointestinal cancer patients participated in this study. The average (standard deviation) FoP score in patients was 32.94  ±  10.64. The average score of CLS was 17.65  ±  6.71, and that for the HHI was 31.27  ±  7.73. Pearson correlation analysis showed that FoP was negatively significant correlated with hope level (r = −0.522) and FoP was positively significant correlated with loneliness (r = 0.545). Linear regression analysis showed that educational level, age, living condition, hope, and loneliness were the significant predictors of FoP and explained 53.10% of the variability in FoP (F = 16.372).ConclusionFindings highlight the need to strengthen attention to FoP in gastrointestinal cancer patients. Our study showed that gastrointestinal cancer patients who have a high school education, are age 45 to 59, live alone, high level of loneliness, and low level of hope have higher FoP. Medical staff should enhance clinical screening of FoP and consider the formulation of relevant interventions for high-risk groups to reduce loneliness among patients, raise their hope level, and reduce their FoP.

引言近年来，疾病进展恐惧（FoP）已成为癌症患者中最常见的心理问题之一。然而，关于胃肠道肿瘤患者疾病进展恐惧的研究相对较少。本研究旨在评估胃肠道肿瘤患者疾病进展恐惧的水平，并分析与之相关的因素。此外，本研究还旨在探讨孤独感、希望与胃肠道癌症患者疾病进展恐惧之间的关系。
方法本研究于2021年11月至2022年7月在中国西南部三所甲级医院进行了横断面调查。研究内容包括人口统计学和临床特征问卷、疾病进展恐惧量表（FoP-Q-SF）、癌症孤独量表（CLS）和Herth希望指数（HHI）。数据分析包括描述性统计、独立样本t检验、单因素方差分析和多元线性回归分析。
结果本研究共纳入245例胃肠道癌症患者。患者疾病进展恐惧的平均（标准差）得分为32.94 ± 10.64。癌症孤独量表的平均得分为17.65 ± 6.71，Herth希望指数的平均得分为31.27 ± 7.73。皮尔逊相关分析显示，疾病进展恐惧与希望水平呈负显著相关（r =−0.522），与孤独感呈正显著相关（r =0.545）。线性回归分析表明，教育水平、年龄、居住条件、希望和孤独感是疾病进展恐惧的显著预测因素，并解释了疾病进展恐惧变异性的53.10%（F =16.372）。
结论研究结果强调了加强关注胃肠道癌症患者疾病进展恐惧的必要性。本研究显示，具有高中教育水平、年龄在45至59岁之间、独居、孤独感程度高且希望水平低的患者，其疾病进展恐惧程度较高。医务人员应加强疾病进展恐惧的临床筛查，并考虑为高风险群体制定相关干预措施，以降低患者的孤独感，提高其希望水平，并减轻其疾病进展恐惧。