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Chip-chip from HepG2 cells and HepG2 cells with slug overexpression

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE41027
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The transcription factor slug represses genes with E-box and then activates cancer stem cell related pathway: Wnt, Notch and Hedgehog pathway. Chromatin immunoprecipitation (ChIP) of slug by ChIP-on-chip analysis demonstrated that slug indirectly activates cancer stem cell related pathway and thus promotes vasculogenic mimicry formation. Comparison of HepG2-control in regular culture, HepG2-slug in regular culture and HepG2-slug on Matrigel.
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2012-09-24
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