CAGED: CAMPYLOBACTER GENOMICS AND ENVIRONMENTAL ENTERIC DYSFUNCTION

The project seeks to understand the livestock reservoirs for Campylobacter infection. It aims to gain insight into Campylobacter species composition, genomic diversity, and its presence in livestock and how they are related to these bacteria in the gut of young children. The study addresses the following objectives,1) Assess the prevalence, species composition, and genomic diversity of thermotolerant and non-thermotolerant Campylobacter species in young children, adults, livestock, and other reservoirs in the rural area of eastern Ethiopia2) Determine the attribution of Campylobacter infections in young children to humans, livestock, and other reservoirs (i.e. drinking water, soil) based on the genetic population structure of Campylobacter species circulating in these reservoirs3) Assess associations among the presence of Campylobacter species, gut microbiota, and the health status of children