Structure-Activity and Metabolic Relationships of 2-Aminobenzimidazole Antimalarials

Malaria is a major burden on global health and infects over 200 million people every year, 619,000 of these infections resulted in death in 2021. Currently available medicines are not working as well in the field as the parasite that causes malaria has developed resistance, so new drugs are urgently required. This research focused on the design and chemical synthesis of a new series of antimalarial compounds which were tested in malarial parasites to determine potency. The best compounds were then assessed for stability in the liver to ensure long lasting effects in the body to clear the parasite infection.