SRSF2

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010]

该基因编码的蛋白质属于富含丝氨酸/精氨酸（SR）的预mRNA剪接因子家族，该家族构成剪接体的一部分。每个因子均含有RNA识别基序（RRM）以结合RNA，并含有一个RS结构域以结合其他蛋白质。RS结构域富含丝氨酸和精氨酸残基，有利于不同SR剪接因子之间的相互作用。除了对mRNA剪接至关重要之外，SR蛋白亦已被证实参与mRNA从细胞核的输出及翻译过程。针对该基因，已发现两种编码相同蛋白质的转录本变体以及一种非编码转录本变体。此外，在11号染色体上还发现了一种该基因的假基因。[由RefSeq提供，2010年9月]