Study on the Pathogenic Role and Mechanism of ADAMTS4 in Ulcerative Colitis

ADAMTS4 is an enzyme with proteolytic activity, primarily involved in the degradation of the extracellular matrix (ECM). In recent years, the role of ADAMTS4 in various inflammatory diseases has garnered increasing attention. Ulcerative colitis (UC) is a chronic and relapsing inflammatory bowel disease, the etiology and pathogenesis of which remain incompletely understood. This study aims to investigate the pathogenic role and mechanism of ADAMTS4 in UC and evaluate the effects of ADAMTS4 knockout on colitis. Investigating the pathogenic role of ADAMTS4 in UC holds potential significance for providing new therapeutic targets and developing novel therapeutic strategies for UC. Overall design: RNA-Seq was performed on ADAMTS4 knockout mice and WT mice after 7 days of DSS treatment.