Vascular anomalies alpelisib treatment. Personalized molecularly guided treatment of patients with vascular malformations harboring PIK3CA and TEK mutation

Sequencing results from a single-center, prospective cohort study of 11 patients with large and debilitating vascular anomalies with one or more major systemic complications who underwent molecular genetic analysis using either whole-exome sequencing, targeted gene panel sequencing, or direct sequencing of TEK exon 17 by Sanger’s method.