Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution

Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... Authors: Pantel, L, Florin, T, Dobosz-Bartoszek, M, Racine, E, Sarciaux, M, Serri, M, Houard, J, Campagne, J.M, Marcia de Figueiredo, R, Midrier, C, Gaudriault, S, Givaudan, A, Lanois, A, Forst, S, Aumelas, A, Cotteaux-Lautard, C, Bolla, J.M, Vingsbo Lundberg, C, Huseby, D, Hughes, D, Villain-Guillot, P, Mankin, A.S, Polikanov, Y.S, Gualtieri, M. Deposit date: 2018-01-30 Release date: 2018-04-18 Last modified: 2025-03-19 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site. Mol. Cell, 70, 2018

分辨率为2.6 Å的、结合NOSO-95179抗生素并与mRNA以及A、P、E位点tRNA复合的嗜热栖热菌（Thermus thermophilus）70S核糖体晶体结构。描述符：16S核糖体RNA（16S Ribosomal RNA）、23S核糖体RNA（23S Ribosomal RNA）、30S核糖体蛋白S10（30S ribosomal protein S10）等。作者：Pantel, L、Florin, T、Dobosz-Bartoszek, M、Racine, E、Sarciaux, M、Serri, M、Houard, J、Campagne, J.M、Marcia de Figueiredo, R、Midrier, C、Gaudriault, S、Givaudan, A、Lanois, A、Forst, S、Aumelas, A、Cotteaux-Lautard, C、Bolla, J.M、Vingsbo Lundberg, C、Huseby, D、Hughes, D、Villain-Guillot, P、Mankin, A.S、Polikanov, Y.S、Gualtieri, M。提交日期：2018-01-30；发布日期：2018-04-18；最后修改日期：2025-03-19。实验方法：X射线衍射（X-RAY DIFFRACTION，2.6 Å）。引用文献：《Odilorhabdins：通过结合核糖体新位点引发错码的抗菌剂》，《Mol. Cell》，70卷，2018年。