Natural xanthones as α-Mangostin induce vasorelaxation involving key gating residues in the S6 domain of BK channels

The xanthone Mangostin from Garcinia mangostana was described as a potent modulator of several potassium channels, with large-conductance K+ (BK) channels as its primary target for vasorelaxation. The dataset compiles electrophysiological source data for the potassium channel screen, the characterization of Mangostin activation in BK channels, as well as the vascular BK/β1 subunit complex and reconstituted BK-Cav nanodiomains in whole-cell recordings. It further contains results of single-channel recordings, the files generated in molecular docking, and the force measurement data in native aortic tissue. These findings establish BK channel activation as the core molecular mechanism driving Mangostin’s vascular effects and define its structural mode of action, informing nutraceutical safety assessment and BK-targeted drug design. , , , # Data from: Natural xanthones as α-Mangostin induce vasorelaxation involving key gating residues in the S6 domain of BK channels Dataset DOI: [10.5061/dryad.x69p8d00j](https://doi.org/10.5061/dryad.x69p8d00j) ## Description of the data and file structure We have submitted all data points underlying the figures in our manuscript. This includes (i) data of single-channel and whole-cell patch clamp measurements, (ii) input and result files from molecular docking experiments as well as a result summary, (iii) data from contraction force measurements of murine aortic tissue preparations. ### Files and variables #### File: potassium_channel_screen.xlsx **Description:** Mangostin modulation of different potassium channel family members, voltage clamp measurements in whole-cell configuration **Structure:** column A: channel name, column B: basal current in nA, column C: Mangostin-activated current in nA; rows contain repeated measurements. Currents are given in nA. #### File: BK_data.x...,