Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P200

Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P200 Descriptor: 1,2-ETHANEDIOL, 3-(2-{[(4-chlorophenyl)carbamoyl]amino}propan-2-yl)-N-hydroxybenzene-1-carboximidamide, DI(HYDROXYETHYL)ETHER, ... Authors: Maltseva, N, Kim, Y, Mulligan, R, Makowska-Grzyska, M, Gu, M, Gollapalli, D.R, Hedstrom, L, Joachimiak, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2017-02-27 Release date: 2017-03-22 Last modified: 2026-03-25 Method: X-RAY DIFFRACTION (2.367 Å) Cite: Role of the Mobile Active Site Flap in IMP Dehydrogenase Inhibitor Binding. Acs Infect Dis., 11, 2025

产气荚膜梭菌来源的、与次黄嘌呤核苷5'-一磷酸（IMP）及P200配体复合的次黄嘌呤核苷5'-一磷酸脱氢酶晶体结构，所含配体包括：1,2-乙二醇、3-(2-{[(4-氯苯基)氨基甲酰]氨基}丙-2-基)-N-羟基苯-1-甲脒、二(羟乙基)醚等。作者：Maltseva N、Kim Y、Mulligan R、Makowska-Grzyska M、Gu M、Gollapalli D.R.、Hedstrom L、Joachimiak A、Anderson W.F.，传染病结构基因组学中心（Center for Structural Genomics of Infectious Diseases, CSGID）。提交日期：2017-02-27；发布日期：2017-03-22；最后修改日期：2026-03-25。实验方法：X射线衍射（分辨率2.367 Å）。引用文献：《可移动活性位点瓣在次黄嘌呤核苷5'-一磷酸脱氢酶抑制剂结合中的作用》，《ACS感染性疾病杂志》，2025年，第11卷。