Effect of progerin on genes involved in progeria

The effect of progerin on the involved genes in progeria, also known as Hutchinson-Gilford progeria syndrome (HGPS). Each colored box shows a different element of the pathway. The red box on the upper right shows that upregulation of the p53 pathway leads to apoptosis and senescence. The box beneath the red one, the purple one, indicates the inhibition of the Wnt pathway by progerin which results in bone abnormalities. The blue box portrays the epigenetic changes done by heterochromatin and euchromatin silencing. The green box shows that progerin activates SKIP which stimulates the Notch signaling pathway. The orange box surrounds the Mi-2/NuRD complex which is depleted by progerin leading mainly to epigenetic changes. The final yellow box shows the inhibition of SERBP1 by progerin resulting in dysfunctional adipose tissue. Legend shows basic and MIM-interactions and indication for methylation.

探究早老素对早老症相关基因的影响，亦称赫奇森-吉尔福德早老症（HGPS）。每一彩色框代表通路中的不同元素。右上角的红色框显示p53通路的上调导致细胞凋亡和衰老。红色框下方的紫色框表明，早老素抑制Wnt通路，从而导致骨骼异常。蓝色框描绘了由异染色质和常染色质沉默所引起的表观遗传变化。绿色框表明，早老素激活SKIP，从而刺激Notch信号通路。橙色框包围着Mi-2/NuRD复合物，早老素使其耗竭，主要导致表观遗传变化。最后的黄色框显示，早老素抑制SERBP1，导致脂肪组织功能异常。图例展示了基本和MIM的相互作用以及甲基化的指示。