Coordination of Methyl Coenzyme M and Coenzyme M at Divalent and Trivalent Nickel Cyclams: Model Studies of Methyl Coenzyme M Reductase Active Site
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https://figshare.com/articles/dataset/Coordination_of_Methyl_Coenzyme_M_and_Coenzyme_M_at_Divalent_and_Trivalent_Nickel_Cyclams_Model_Studies_of_Methyl_Coenzyme_M_Reductase_Active_Site/2539117
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资源简介：
Divalent and trivalent nickel complexes of 1,4,8,11-tetraazacyclotetradecane,
denoted as cyclam hereafter, coordinated by methyl coenzyme M (MeSCoM–) and coenzyme M (HSCoM–) have been
synthesized in the course our model studies of methyl coenzyme M reductase
(MCR). The divalent nickel complexes Ni(cyclam)(RSCoM)2 (R = Me, H) have two trans-disposed RSCoM– ligands
at the nickel(II) center as sulfonates, and thus, the nickels have
an octahedral coordination. The SCoM2– adduct Ni(cyclam)(SCoM)
was also synthesized, in which the SCoM2– ligand
chelates the nickel via the thiolate sulfur and a sulfonate oxygen.
The trivalent MeSCoM adduct [Ni(cyclam)(MeSCoM)2](OTf)
was synthesized by treatment of [Ni(cyclam)(NCCH3)2](OTf)3 with (nBu4N)[MeSCoM]. A similar reaction with (nBu4N)[HSCoM] did not afford the corresponding trivalent
HSCoM– adduct, but rather the divalent nickel complex
polymer [−NiII(cyclam)(CoMSSCoM)−]n was obtained, in which the terminal thiol of HSCoM– was oxidized to the disulfide (CoMSSCoM)2– by the Ni(III) center.
创建时间：
2012-03-19
