The Cancer Genome Atlas Urothelial Bladder Carcinoma Collection (TCGA-BLCA)

The Cancer Genome Atlas Urothelial Bladder Carcinoma (TCGA-BLCA) data collection is part of a larger effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from The Cancer Genome Atlas (TCGA). Clinical, genetic, and pathological data resides in the Genomic Data Commons (GDC) Data Portal while the radiological data is stored on The Cancer Imaging Archive (TCIA). Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes. Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type. For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols. In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial癌症基因组图谱膀胱尿路上皮癌（TCGA-BLCA）数据集是一项更大规模研究计划的组成部分，该计划旨在构建一个研究共同体，通过为癌症基因组图谱（The Cancer Genome Atlas, TCGA）项目的受试者匹配临床影像，实现癌症表型与基因型的关联研究。临床、遗传与病理数据存储于基因组数据共享（Genomic Data Commons, GDC）数据门户，而放射学影像数据则存档于癌症影像档案（The Cancer Imaging Archive, TCIA）。匹配后的TCGA患者标识符可支持研究人员在TCGA与TCIA数据库中，探究组织基因型、放射学表型与患者预后之间的关联。为达成每种癌症类型约500份样本的招募目标，TCGA项目的组织样本采自全球多个采集站点。正因如此，该影像数据集在扫描模态、设备厂商与采集协议方面均呈现出极强的异质性。在多数情况下，这些影像均为常规诊疗流程中产生的结果，而非受控研究或临床试验的专属采集数据。

搜集汇总

背景与挑战

背景概述

该数据集是TCGA膀胱尿路上皮癌的影像与临床基因组数据集合，用于研究癌症表型与基因型之间的关联。图像数据来自常规诊疗，具有扫描仪、制造商和采集协议的高度异质性，便于研究者探索组织基因型与放射学表型、患者结局的相关性。