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Maintenance and resurrection of retinal pigmented epithelial cell phenotype by type 1 TGF-beta receptor kinase inhibitors

ChEBI2015-07-06 更新2026-07-12 收录

视网膜色素上皮细胞研究

TGF-β信号通路调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-62224 数据链接链接失效反馈

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Maintenance and resurrection of retinal pigmented epithelial cell phenotype by type 1 TGF-beta receptor kinase inhibitors

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创建时间：

2015-07-06

TGF-β信号通路调控

磷酸酶与肿瘤抑制

The tumor suppressor Smad4, a key mediator of the TGF-?/BMP pathways, is essential for development and tissue homeostasis. Phosphorylation of Smad4 in its linker region catalyzed by the mitogen-activa

NIAID Data Ecosystem140

Study of three-dimensional structure of chromatin through a 4C-seq experiment in mouse NSC shControl and shJMJD3 upon TGFβ treatment [Chst8]

染色质三维构象分析

TGF-β信号通路调控

In this study we analyzed how multiple enhancers arrange in the 3D-space to control the activation of a specific promoter. Specifically, we did a 4C-seq experiment on a ~374 Kb locus where enhancers a

NIAID Data Ecosystem70

A High-dose of genistein down-regulates TGF-beta pathway genes in human uterine leiomyoma cells. Homo sapiens

子宫平滑肌肿瘤分子机制

TGF-β信号通路调控

High doses of genistein show an inhibitory effect on uterine leiomyoma (UtLM) cell proliferation. Using microarray analysis and Ingenuity Pathways AnalysisTM, we identified genes (up- or down-regulate

NIAID Data Ecosystem20

Glucocorticoid receptor inhibits transforming growth factor-β signaling by directly targeting the transcriptional activation function of Smad3

糖皮质激素信号调控

TGF-β信号通路调控

The transforming growth factor-β (TGF-β) family of cytokines and glucocorticoids regulate diverse biological processes through modulating the expression of target genes. Here we report that glucocorti

PubMed Central1999-10-12 更新90

Expression data from TGF-beta-treated human ovarian fibroblasts

癌微环境

TGF-β信号通路调控

Advanced ovarian cancer is the most lethal gynecologic malignancy in the United States. Ovarian cancer cells are known to have diminished response to TGF-beta, but it remains unclear whether TGF-beta

NIAID Data Ecosystem40

Maintenance and resurrection of retinal pigmented epithelial cell phenotype by type 1 TGF-beta receptor kinase inhibitors

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