SIRT6 and SIRT1 contribute to circadian gene expression
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SIRT6 and SIRT1 contribute to circadian gene expression
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2014-08-05
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Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease. Homo sapiens
Background: Maintenance of physiological circadian rhythm plays a crucial role in human health. Numerous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychia
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Chromatin dynamics reveal circadian control of human in vitro islet maturation [WGBS]. Chromatin dynamics reveal circadian control of human in vitro islet maturation [WGBS]
Stem cell-derived tissues could transform disease research and therapy, yet most methods generate functionally immature products. We investigate how human stem cells differentiate into pancreatic isle
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Human SIRT6 crystal structure in complex with 2'-N-Acetyl ADP ribose
Human SIRT6 crystal structure in complex with 2'-N-Acetyl ADP ribose Descriptor: NAD-dependent deacetylase sirtuin-6, SULFATE ION, UNKNOWN ATOM OR ION, ... Authors: Pan, P.W, Dong, A, Qiu, W, Loppnau,
Protein Data Bank Japan2023-09-06 更新50
Drug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer towards androgen-independence [Cell line ChIP-Seq]
In prostate cancer, androgen receptor (AR)-targeting agents are very effective in various stages of the disease. However, therapy resistance inevitably occurs and little is known about how tumor cells
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Additional file 3: of Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease
Proportion of variance explained by oscillations at various EVCs thresholds. Number of total EVCs, percent of oscillating EVCs, and summary of oscillating principal component scores at different EVC s
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