Targeted deletion of mouse Slc25a28 (Mitoferrin2) reveals Mitoferrin1 and Mitoferrin2 are necessary for liver regeneration and cell proliferation. Targeted deletion of mouse Slc25a28 (Mitoferrin2) reveals Mitoferrin1 and Mitoferrin2 are necessary for liver regeneration and cell proliferation

Hepatocyte-specific loss of Slc25a37 (Mitoferrin1) in Mitoferrin2-/- mice did not affect animal viability or liver size suggesting that there must be alternative hepatocyte mitochondrial iron importers that function in the absence of Mitoferrins. Overall design: Liver mRNA profiles from aged-matched controls and hepatocyte-specific loss of both mitoferrins (Alb-cre Mfnr1-/- Mfrn2-/-) animals.