Cryo-EM structure of the human mitochondrial RNA polymerase transcription initiation complex (POLRMT/TFAM/TFB2M/DNA/RNA) with a slipped 3-mer RNA (pppGpGpA) and GTP poised for catalysis (slipped pre-IC4)

Cryo-EM structure of the human mitochondrial RNA polymerase transcription initiation complex (POLRMT/TFAM/TFB2M/DNA/RNA) with a slipped 3-mer RNA (pppGpGpA) and GTP poised for catalysis (slipped pre-IC4) Descriptor: DNA-directed RNA polymerase, mitochondrial, Dimethyladenosine transferase 2, ... Authors: Goovaerts, Q, Shen, J, Ajjugal, Y, De Wijngaert, B, Patel, S.S, Das, K. Deposit date: 2025-05-19 Release date: 2025-07-30 Last modified: 2025-09-03 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Human mitochondrial RNA polymerase structures reveal transcription start site and slippage mechanism. Mol.Cell, 85, 2025人类线粒体RNA聚合酶转录起始复合物（POLRMT/TFAM/TFB2M/DNA/RNA）的冷冻电镜（Cryo-EM）结构，该复合物携带滑动型3聚体RNA（pppGpGpA）与处于催化待命状态的GTP（滑动型pre-IC4） 描述项：线粒体DNA指导的RNA聚合酶、二甲基腺苷转移酶2，…… 作者：Goovaerts Q、Shen J、Ajjugal Y、De Wijngaert B、Patel S.S、Das K. 提交日期：2025-05-19 发布日期：2025-07-30 最后修改日期：2025-09-03 实验方法：电子显微镜（3.1埃） 引用文献：人类线粒体RNA聚合酶结构揭示转录起始位点与滑动机制，《分子细胞》（Mol.Cell），第85卷，2025年