Characterization of the EAE animal model and the clinical parameters of EAE rats prior to and after treatment with antagonists of glutamatergic receptors.

The values represent the means ± SD. *P<0.05 indicates significant differences compared with the EAE rats. Combined administration of LY 367385 or MPEP in combination with the NMDAR antagonists (amantadine and memantine) did not influence the neurological deficits or the condition of the experimental rats during the course of the disease. The neurological deficits and condition of the examined animals were the same as in the case of treatment with amantadine or memantine exclusively (data not presented). CI – cumulative index.
Characterization of the EAE animal model and the clinical parameters of EAE rats prior to and after treatment with antagonists of glutamatergic receptors.