Gut microbiota of an immunocompromised child with chronic cryptosporidiosis

Here, we describe a case of chronic cryptosporidiosis in a European child with severe CD40L immunodeficiency infected with Cryptosporidium parvum of the IIa20G1 subgenotype, a lineage which has thus far only ever been described in the Middle East. After years of on off treatment with conventional and non conventional antiparasitic drugs failed to clear parasitosis, we performed targeted metagenomics to observe the bacterial composition of the patient's gut microbiota in response to chronic cryptosporidiosis.