Cyclin A/B1/B2 associated events during G2/M transition

Cell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions. The G2/M transition is regulated through the phosphorylation of nuclear lamins and histones (reviewed in Sefton, 2001).<br>The two B-type cyclins localize to different regions within the cell and are thought to have specific roles as CDK1-activating subunits (see Bellanger et al., 2007). Cyclin B1 is primarily cytoplasmic during interphase and translocates into the nucleus at the onset of mitosis (Jackman et al., 1995; Hagting et al., 1999). Cyclin B2 colocalizes with the Golgi apparatus and contributes to its fragmentation during mitosis (Jackman et al., 1995; Draviam et al., 2001).

细胞周期进程受周期素依赖性蛋白激酶在G1/S和G2/M转换阶段的调控。G2/M转换的调控通过核纤层和组蛋白的磷酸化实现（参见Sefton，2001年的综述）。两种B型周期素定位于细胞的不同区域，并被认为是CDK1激活子单位的特定角色（参见Bellanger等，2007年的研究）。周期素B1在间期主要位于细胞质中，并在有丝分裂开始时转移至细胞核（参见Jackman等，1995年；Hagting等，1999年的研究）。周期素B2与高尔基体共定位，并在有丝分裂期间促进其裂解（参见Jackman等，1995年；Draviam等，2001年的研究）。