Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 9

Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 9 Descriptor: 3-[(2R)-2-oxidanyl-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Jain, V, Manickam, Y, Sharma, A. Deposit date: 2017-04-26 Release date: 2018-03-07 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017

刚地弓形虫（Toxoplasma gondii）脯氨酰-tRNA合成酶（Prolyl-tRNA Synthetase，TgPRS）与抑制剂9共晶的晶体结构。抑制剂9的标识为3-[(2R)-2-羟基-3-[(2R,3R)-3-羟基哌啶-2-基]丙基]喹唑啉-4-酮，共晶组分包含镁离子、磷氨酰磷酸-腺苷酯等。作者：Jain, V、Manickam, Y、Sharma, A。存储日期：2017-04-26；发布日期：2018-03-07；最后修改日期：2023-11-22。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.5 Å）。引用文献：《靶向脯氨酰-tRNA合成酶以加速抗疟疾、利什曼病、弓形虫病、隐孢子虫病和球虫病的药物发现》，《Structure》，2017年，第25卷。