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Bulk RNA transcriptomic analysis of logic-gated CAR-T cells targeting a combination of CD33 and CD123 in AML

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP546502
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We identified a gene set that is differentially expressed in gated versus constitutively expressed CAR-T cells, often pointing to naive and unstimulated genes in gated CAR-T cells, in contrast to constitutive CAR-T cells Overall design: We performed bulk RNA analysis on T cells isolated from CAR-T co-culture with AML MOLM13 cell line at 48 hours from 3 different donors
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2024-12-03
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