Summary of adverse events in Part 1 (SD) and Part 2 (RD).

*Only those occurring in ≥4 subjects across all cohorts are listed.†Five unreported AEs were identified (in 3 subjects): 1 subject experienced severe diarrhea (2.5 mg/kg), 1 subject experienced shoulder pain, secondary to muscle biopsy (15 mg/kg), and 1 subject experienced some minor skin bruising, a fall and a hard swelling on the left hip (resulting from the fall) (15 mg/kg).**Two doses, received 4 weeks apart.‡Only those occurring in ≥2 subjects across all cohorts are listed. AE, adverse event; n, number of subjects; SD, single dose; RD, repeated dose.