CREBBP bromodomain in complex with Cpd 4 (1-(1-(cyclopropylmethyl)-3-(1H-indol-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)

CREBBP bromodomain in complex with Cpd 4 (1-(1-(cyclopropylmethyl)-3-(1H-indol-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one) Descriptor: 1,2-ETHANEDIOL, 1-[1-(cyclopropylmethyl)-3-(1H-indol-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]ethan-1-one, CREB-binding protein, ... Authors: Murray, J.M. Deposit date: 2017-08-07 Release date: 2018-08-08 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.391 Å) Cite: Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300. Bioorg. Med. Chem. Lett., 28, 2018

CREBBP溴结构域（CREBBP bromodomain）与化合物4（Cpd 4，化学名对应1-(1-(环丙基甲基)-3-(1H-吲哚-4-基)-1,4,6,7-四氢-5H-吡唑并[4,3-c]吡啶-5-基)乙-1-酮）形成的复合物。描述项：1,2-乙二醇、1-[1-(环丙基甲基)-3-(1H-吲哚-4-基)-1,4,6,7-四氢-5H-吡唑并[4,3-c]吡啶-5-基]乙-1-酮、CREB结合蛋白（CREB-binding protein）……作者：Murray, J.M. 提交日期：2017-08-07 发布日期：2018-08-08 最后修改日期：2023-10-04 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.391 Å） 引用文献：《联芳基类CBP/P300溴结构域抑制剂的设计与合成》，《Bioorganic & Medicinal Chemistry Letters》（Bioorg. Med. Chem. Lett.），2018年，第28卷。