Lincomycin and Avilamycin bound to the 50S subunit

Lincomycin and Avilamycin bound to the 50S subunit Descriptor: (2R,3S,4R,6S)-4-hydroxy-6-{[(2R,3aR,4R,4'R,5'S,6S,6'R,7aR)-4'-hydroxy-6-{[(2S,3R,4R,5S,6R)-3-hydroxy-2-{[(2R,3S,4S,5S,6S)-4-hydroxy-6-({(2R,3aS,3a'R,6S,6'R,7R,7'R,7aR,7a'R)-7'-hydroxy-7'-[(1S)-1-hydroxyethyl]-6'-methyl-7-[(2-methylpropanoyl)oxy]octahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl}oxy)-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl]oxy}-4,6',7a-trimethyloctahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-5'-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate (non-preferred name), 23S rRNA, 50S ribosomal protein L15, ... Authors: Paternoga, H, Crowe-McAuliffe, C, Beckert, B, Wilson, D.N. Deposit date: 2023-02-05 Release date: 2023-07-19 Last modified: 2026-06-24 Method: ELECTRON MICROSCOPY (1.64 Å) Cite: Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023结合于50S亚基（50S subunit）的林可霉素（Lincomycin）与阿维拉霉素（Avilamycin），标识符：(2R,3S,4R,6S)-4-羟基-6-{[(2R,3aR,4R,4'R,5'S,6S,6'R,7aR)-4'-羟基-6-{[(2S,3R,4R,5S,6R)-3-羟基-2-{[(2R,3S,4S,5S,6S)-4-羟基-6-({(2R,3aS,3a'R,6S,6'R,7R,7'R,7aR,7a'R)-7'-羟基-7'-[(1S)-1-羟乙基]-6'-甲基-7-[(2-甲基丙酰)氧基]八氢-4H-2,4'-螺双[[1,3]二氧杂环戊烯并[4,5-c]吡喃]-6-基}氧基)-5-甲氧基-2-(甲氧基甲基)四氢-2H-吡喃-3-基]氧基}-5-甲氧基-6-甲基四氢-2H-吡喃-4-基]氧基}-4,6',7a-三甲基八氢-4H-螺[1,3-二氧杂环戊烯并[4,5-c]吡喃-2,2'-吡喃]-5'-基]氧基}-2-甲基四氢-2H-吡喃-3-基 3,5-二氯-4-羟基-2-甲氧基-6-甲基苯甲酸酯（非惯用名），23S核糖体RNA（23S rRNA）、50S核糖体蛋白L15（50S ribosomal protein L15）等。作者：帕特诺加（Paternoga, H）、克罗-麦考利夫（Crowe-McAuliffe, C）、贝克特（Beckert, B）、威尔逊（Wilson, D.N.）。提交日期：2023-02-05。发布日期：2023-07-19。最后修改日期：2026-04-01。实验方法：电子显微术（分辨率1.64埃）。引用文献：《抗生素与核糖体相互作用的结构保守性》，《自然·结构与分子生物学》（Nat.Struct.Mol.Biol.），第30卷，2023年。