Crystal structure of compound 1 bound to K-Ras(G12D)
收藏Protein Data Bank Japan2024-10-16 更新2026-04-19 收录
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Crystal structure of compound 1 bound to K-Ras(G12D) Descriptor: 4-{(1R,5S)-3-[(7P)-7-(8-ethynylnaphthalen-1-yl)-8-fluoro-2-{[(4s,7as)-tetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl}-4-oxobutanoic acid, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Zhang, Z, Zheng, Q, Guiley, K.Z, Shokat, K.M. Deposit date: 2023-06-10 Release date: 2024-03-13 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D. Nat.Chem.Biol., 20, 2024
创建时间：
2023-06-10
