Antimicrobial Susceptibility Survey of Invasive Haemophilus influenzae, United States 2016

Susceptibility of 700 invasive H. influenzae isolates, collected through US population-based surveillance during 2016, was assessed for 15 antibiotics using broth microdilution, according to the Clinical Laboratory Standards Institute guidelines; a subset of 104 isolates were also assessed for rifampin susceptibility by Etest. Genomes were sequenced to identify genes and mutations known to be associated with reduced susceptibility to clinically relevant drugs.