MOPED

Multi-omics data-driven scientific discovery crucially rests on high-throughput technologies and data sharing. Currently, data are scattered across single omics repositories, stored in varying raw and processed formats, and are often accompanied by limited or no metadata. The Multi-Omics Profiling Expression Database (MOPED, http://moped.proteinspire.org ) version 2.5 is a freely accessible multi-omics expression database. Continual improvement and expansion of MOPED is driven by feedback from the Life Sciences Community. In order to meet the emergent need for an integrated multi-omics data resource, MOPED 2.5 now includes gene relative expression data in addition to protein absolute and relative expression data from over 250 large-scale experiments. To facilitate accurate integration of experiments and increase reproducibility, MOPED provides extensive metadata through the Data-Enabled Life Sciences Alliance (DELSA Global, http://delsaglobal.org ) metadata checklist. MOPED 2.5 has greatly increased the number of proteomics absolute and relative expression records to over 500,000, in addition to adding more than four million transcriptomics relative expression records. MOPED has an intuitive user interface with tabs for querying different types of omics expression data and new tools for data visualization.

以多组学数据驱动的科学发现，核心依托高通量技术与数据共享。当前，各类组学数据分散于单一组学数据库中，存储格式的原始态与处理态各不统一，且往往伴随元数据（metadata）缺失或标注有限的问题。Multi-Omics Profiling Expression Database (MOPED，http://moped.proteinspire.org ) 2.5版本是一款可免费获取的多组学表达数据库。该库的持续优化与扩容，源于生命科学社区的反馈。为满足集成式多组学数据资源的迫切需求，MOPED 2.5 除收录来自250余项大规模实验的蛋白质绝对与相对表达数据外，新增了基因相对表达数据。为助力实验的精准整合并提升研究可重复性，MOPED 依托数据赋能生命科学联盟（Data-Enabled Life Sciences Alliance, DELSA Global，http://delsaglobal.org ）的元数据检查表，提供了丰富详尽的元数据。MOPED 2.5 的蛋白质组学绝对与相对表达记录数已大幅增至50余万条，同时新增了超400万条转录组学相对表达记录。该库配备直观易用的用户界面，设有用于查询不同类型组学表达数据的标签页，以及全新的数据可视化工具。

搜集汇总

背景与挑战

背景概述

MOPED是一个免费的多组学表达数据库，包含超过250个大规模实验的基因和蛋白质表达数据，提供超过500,000个蛋白质组学记录和400万个转录组学记录。该数据库具有丰富的元数据和直观的用户界面，支持数据查询和可视化。