MicroRNA expression data in the liver of offspring with maternal tobacco exposure

We used microarrays to evaluate effects of prenatal exposure to maternal cigarette smoke on the liver in offspring. We observed that among miRNAs with >1.5-fold change value, 28 miRNAs were upregulated and 64 miRNAs were downregulated. Among these miRNAs, the most profoundly altered one was miR-34a-5p with a fold change of -4.379 (p = 0.007). On day 6 after pregnancy, pregnant dams were exposed to mainstream cigarette smoke (600 μg/L; CS600) or filtered clean (Cont) air for 2 hours a day, 5 days a week for two weeks using a nose-only exposure system. Male offspring mice were studied at postnatal week 4. Microarray analysis carried out in Cont and CS600 groups without any liver injuries to explore potential hepatic miRNAs that might be affected by maternal smoking.