Impact of various high fat diets on intestinal gene expression in mouse

High fat diets (HFDs) are linked to several diseases including obesity, diabetes, insulin resistance, fatty liver, and susceptibility to inflammatory bowel disease (IBD) in both mouse and humans. RNA-seq from male mice (C57BL/6N) fed Vivarium Chow (VIV) or any one of three high fat diets (40% kcal fat) (SO+CO, PL+CO, CO) for 24 weeks was performed on four segments of the intestinal tract (Duodenum, Jejunum, Terminal Ileum and Proximal Colon). Overall design: In this study, we analyzed the impact of three high fat diets (HFDs) on gene expression in four functionally distinct segments of the mouse intestinal tract using RNA-seq. The diets are described in Deol et al, 2017 (PMID: 28970503).