Effect of Candida albicans on Pseudomonas aeruginosa gene expression

Pseudomonas aeruginosa and Candida albicans often co-colonize niches or body sites in humans. One of these sites is the gut. We have found that C. albicans inhibits P. aeruginosa virulence in the setting of neutropenia (which emulates how cancer and stem cell transplant patients develop gram-negative bacteremia). In an effort to understand how this inhibitions occurs, we performed in vivo transcription profiling of P. aeruginosa in mice that were mono-colonized with P. aeruginosa and mice that were co-colonized with P. aeruginosa and C. albicans