Additional file 2 of Cis-meQTL for cocaine use-associated DNA methylation in an HIV-positive cohort show pleiotropic effects on multiple traits

Additional file 2: Supplementary Table 1. Candidate CpG sites for cocaine use after meta-analysis to combine results for the 450K and EPIC cohorts (Ntotal = 811). Supplementary Table 2. Selected SNP-CpG pairs (FDR < 0.05) after meta-analysis to combine results for the 450K and EPIC cohorts (Ntotal = 811) and clumping. Supplementary Table 3. Enriched Ingenuity Canonical Pathways identified using genes mapped by the meQTLs for cocaine-related DNA methylations. Supplementary Table 4. Significant traits associated with the top index meQTLs. A total of 60 studies reached the significance level after bonferroni correction (p < 1.7e-7), which consisted of 36 phenotypes (phenotype number). Supplementary Table 5. meQTLs trait enrichment using associates downloaded from GWAS Catalog ( https://www.ebi.ac.uk/gwas/ ). MeQTLs for cocaine-related DNA methylations were used. Supplementary Table 6. Candidate CpG sites for cocaine use frequency (high frequency users VS low frequency users). Supplementary Table 7. MeQTLs (FDR < 0.05) for cocaine use frequency-related DNA methylations after meta-analysis to combine results for the 450K and EPIC cohorts (Ntotal = 293) and clumping. Supplementary Table 8.  Enriched Ingenuity Canonical Pathways identified using genes mapped by the meQTLs for cocaine use frequency-related DNA methylations. Supplementary Table 9. Significant traits associated with the top index meQTLs for cocaine use frequency-related DNA methylations. A total of 4 studies reached the significance level after bonferroni correction (p < 7.0e-7), which consisted of 4 phenotypes (phenotype number). Supplementary Table 10. meQTLs trait enrichment using associates downloaded from GWAS Catalog ( https://www.ebi.ac.uk/gwas/ ). MeQTLs for cocaine use frequency-related DNA methylations were used.