Exploring the Reactivity of Nitro-Activated 1,3-Enynes in an Organocatalytic One-Pot, Three-Component Coupling Reaction: A Tandem Catalytic Approach to a Novel 3‑Nitrochroman Scaffold

A tandem catalytic strategy enabling
one-pot, three-component couplings
of electron-rich phenols, 2-nitro 1,3-enynes, and vinyl ketones was
achieved. This chemistry combined mechanistically distinct [3 + 3]-annulation
and nitro-Michael addition using a single squaramide catalyst, leading
to the construction of novel chiral quaternary 3-nitrochromane architecture
with high chemo-, regio-, and stereoselectivity.