Additional file 2: of Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

Table S1. Tissues used for tissue-specific Mendelian randomization. Table S2. Details on the GWAS datasets used. Table S3. Explanation of the 15 possible scenarios summarizing how variants how can be shared amongst three traits. Table S4. Tissues used for moloc analysis. Table S5. Results of fine-mapping analysis using FINEMAP. Table S6. Tissue-specific Mendelian randomization results for the apoliporotein A1-associated region on chromosone 11 (rs2727784). Table S7. Tissue-specific Mendelian randomization results for the apolipoprotein B-associated region on chromosone 1 (rs646776). Table S8. Tissue-specific Mendelian randomization results for the apolipoprotein B-associated region on chromosone 19 (rs10419998). Table S9. Tissue-specific Mendelian randomization results for the body mass index-associated region on chromosone 2 (rs11693654). Table S10. Tissue-specific Mendelian randomization results for the cholesterol-associated region on chromosone 1 (rs646776). Table S11. Tissue-specific Mendelian randomization results for the cholesterol-associated region on chromosone 11 (rs174538). Table S12. Tissue-specific Mendelian randomization results for the interleukin-6-associated region on chromosone 1 (rs12129500). Table S13. Tissue-specific Mendelian randomization results for the interleukin-6-associated region on chromosone 9 (rs600038). Table S14. Tissue-specific Mendelian randomization results for the low-density lipoprotein-associated region on chromosone 1 (rs646776). Table S15. Tissue-specific Mendelian randomization results for the triglyceride-associated region on chromosone 8 (rs80026582). Table S16. Tissue-specific Mendelian randomization results for the very low-density lipoprotein-associated region on chromosone 8 (rs80026582). Table S17. moloc results for the apolipoprotein B-associated region on chromosone 1. Table S18. moloc results for the cholesterol-associated region on chromosone 1. Table S19. moloc results for the body mass index-associated region on chromosone 2. Table S20. moloc results for the cholesterol-associated region on chromosone 11. Table S21. moloc results for the low-density lipoprotein-associated region on chromosone 1. Table S22. Top findings from applying our pipeline genome-wide for seven cardiovascular traits from GWAS consortia across nine different tissue types. (XLSX 136â kb)