Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas

Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas Descriptor: 5-[4-(2-DIMETHYLAMINOETHYLOXY)PHENYL]-2-UREIDO-THIOPHENE-3-CARBOXAMIDE, SERINE/THREONINE-PROTEIN KINASE CHK1, SULFATE ION Authors: Read, J.A, Breed, J, Haye, H, McCall, E, Rowsell, S, Vallentine, A, White, A. Deposit date: 2011-03-21 Release date: 2012-04-04 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(Piperidin-3-Yl)-3-Ureidothiophene-2-Carboxamide (Azd7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas. J.Med.Chem., 55, 2012

通过基于结构设计与噻吩甲酰胺脲类化合物优化发现检查点激酶抑制剂AZD7762，描述符：5-[4-(2-二甲氨基乙氧基)苯基]-2-脲基-噻吩-3-甲酰胺、丝氨酸/苏氨酸蛋白激酶CHK1、硫酸根离子。作者：Read, J.A、Breed, J、Haye, H、McCall, E、Rowsell, S、Vallentine, A、White, A。沉积日期：2011-03-21；发布日期：2012-04-04；最后修改日期：2024-05-08。实验方法：X射线衍射（1.6 Å）。引用文献：Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(Piperidin-3-Yl)-3-Ureidothiophene-2-Carboxamide (Azd7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas. J.Med.Chem., 55, 2012