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Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (mRNA)

ChEBI2012-06-18 更新2026-07-21 收录

亨廷顿病分子机制

转录因子结合分析

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-38001 数据链接链接失效反馈

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Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (mRNA)

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创建时间：

2012-06-18

结肠基因表达

转录因子结合分析

TF binding clusters in promoter correlate well with gene expression. We used ChIP-seq to map binding sites of the majority of highly expressed TFs in the cell. The size of clusters of TFs in the promo

NIAID Data Ecosystem100

Allele-specific binding analysis of rs242561 by NRF2 ChIP tagmentation sequencing

转录因子结合分析

等位基因特异性

We identified a SNP rs242561, located within a regulatory region of the MAPT gene (encoding microtubule-associated protein Tau). It was consistently occupied by NRF2/sMAF in multiple ChIP-seq experime

NIAID Data Ecosystem30

GABPA ChIP-seq in human monocytic THP-1 cells. Homo sapiens

转录因子结合分析

表观遗传调控

ChIP-seq for GABPA in THP-1 cells after stimulation with the the natural VDR ligand 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) Overall design: THP-1 cells were treated for 24 h with 100 nM 1,25(OH)2D3 or

NIAID Data Ecosystem30

Expression data from 9 and 13 weeks old TIFIAD1Cre mice

亨廷顿病分子机制

神经元基因表达

We have investigated the p53-dependent stress response in medium spiny neurons (MSNs) that degenerate in Huntington’s disease. To induce p53 signaling cascade, we have genetically inactivated by the C

NIAID Data Ecosystem40

Targeting H3K4 methylation as a therapeutic strategy for Huntington's disease (RNA-seq). Mus musculus

亨廷顿病分子机制

表观遗传调控

Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain.

NIAID Data Ecosystem30

Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (mRNA)

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