Supporting data for "Aspects of bioactive glass in dental resin composites"

The files contain the data on the physical, mechanical properties, mineralization ability, in vitro biocompatibility, and antibacterial activities on biofilms formation of low quantities (0.0, 1.9, 3.8, and 7.7 vol%) of BAG-loaded resin composites.  The surface nanohardness of specimens was evaluated by AFM. Compressive strength, flexural strength, flexural modulus, and biaxial flexural strength were evaluated using a universal testing machine. Water sorption and water solubility of resin composites were also evaluated. The mineralization ability, including elemental (Ca, P, and Si) concentration measured by  ICP-OES, pH changes analyzed by pH meteral, and apatite formation assessed using SEM, XRD and FTIR, was also assessed. In addition, in vitro biocompatibility of resin composites, including cell adhesion, cell proliferation, and cell differentiation, was evaluated using live/dead cell staining, CCK-8 kit, ALP assay, and CLSM. Finally, the bacterial viability in S. mutans biofilms was analysed via XTT-assay, CFU counting, live/dead bacterial staining. The antibacteria activities on biofilm structure, biofilm thickenss and cell viability throughout biofilm depth were also assessed.

本数据集收录了低含量（0.0、1.9、3.8和7.7体积比）BAG载体的树脂复合材料的物理、力学性能、矿化能力、体外生物相容性以及生物膜形成过程中的抗菌活性数据。样品的表面纳米硬度通过原子力显微镜进行评估。采用万能试验机对压缩强度、弯曲强度、弯曲模量和双轴弯曲强度进行了测试。树脂复合材料的水吸收率和溶解度也进行了评估。矿化能力，包括通过ICP-OES测量的元素（钙、磷和硅）浓度、pH值变化通过pH计分析，以及利用扫描电子显微镜（SEM）、X射线衍射（XRD）和傅里叶变换红外光谱（FTIR）评估的磷酸钙形成，亦被评估。此外，采用活/死细胞染色、CCK-8试剂盒、碱性磷酸酶（ALP）测定和共聚焦激光扫描显微镜（CLSM）对树脂复合材料的体外生物相容性，包括细胞粘附、细胞增殖和细胞分化进行了评估。最终，通过XTT试验、菌落形成单位（CFU）计数、活/死细菌染色分析了在变形链球菌生物膜中的细菌存活率。同时，对生物膜结构、生物膜厚度以及生物膜深度内的细胞存活率方面的抗菌活性也进行了评估。