Methylation Supernegative Colorectal Cancers - a Key to Unlocking the Secrets of the DNA (de)methylation Machinery, 2019

Cytosine methylation is essential for the proper epigenetic regulation of gene expression and maintenance of genomic integrity. We aim at expanding existing knowledge about the mechanism of the DNA methylation and demethylation machineries by a systematic analysis of a novel and intriguing subgroup of cancers, which have unusually little promoter hypermethylation. These tumors represent a unique opportunity for direct insight into the molecular and cellular (dys)functions of the DNA (de)methylation machinery and will be studied at several levels by a multi-disciplinary team, using state-of-the art technology and bioinformatics. In addition to novel biological insights, the results from this project may be useful in the clinical management of colorectal cancer patients. Recurrent aberrations among the methylation supernegative tumors represent novel biomarkers that can improve the sensitivity of existing DNA methylation based test for early detection of colorectal cancer, and ultimately the survival of this patient group. Finally, we aim at identifying novel prognostic markers that may improve the stratification of colorectal cancer patients. For further information about ”Methylation Supernegative Colorectal Cancers - a Key to Unlocking the Secrets of the DNA (de)methylation Machinery, 2019”, please contact the principal investigator.