Evaluation of Duloxetine effect on Oxaliplatin induced peripheral neuropathy prophylaxis

Intervention 1: Intervention group: patient who take duloxetine 30mg/d for first week and then 30 mg BD to 12 weeks. Intervention 2: Control group: Patients in this group receive one placebo capsule during the first week and then take 2 placebo capsules until 12th week of study.
Primary outcome(s): Peripheral neuropathy. Timepoint: every 2-3 week. Method of measurement: FACT/GOG-NTX-13 and NCI-CTCAE questionaire.
Study Design: Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: In covariate adaptive randomization, a new participant is sequentially assigned to a particular treatment group by taking into account the specific covariates and previous assignments of participants. in this study covariants factors include : 1.sex 2.age 3.cancer stage. we used Graphpad prism for randomization.