Supplemental Material for JAAD-D-26-01408 — Risk-Adapted Monitoring of Melanocytic Lesions With Peripheral Globules: A Longitudinal Cohort Study on Melanoma Risk Stratification

This dataset contains the supplemental material for the article "Risk-Adapted Monitoring of Melanocytic Lesions With Peripheral Globules: A Longitudinal Cohort Study on Melanoma Risk Stratification" (Journal of the American Academy of Dermatology; manuscript JAAD-D-26-01408), by Kaan Gündüz, MD; Handan Merve Erol Mart, MD; Ömer Faruk Şimşek, MD; İlay Özsan, MD; Murat Doğuş Günel, MSc; Ayşe Öktem, MD; Bengü Nisa Akay, MD. Per journal policy, supplemental material is hosted here rather than published with the article. Contents: - Supplementary Methods: Full modeling details, including priors, convergence diagnostics, and model-fit metrics. - Supplementary Results: Details of model convergence, patient-level heterogeneity, and out-of-sample predictive performance. - Supplementary Figure 1: Histopathologically confirmed benign melanocytic nevi with peripheral globules. Six lesions (a-f) biopsied or excised because of documented change, age-related concern, growth or persistence of peripheral globules, or clinical caution during digital monitoring; all benign on histopathology. - Supplementary Figure 2: Histopathologically confirmed melanomas presenting with peripheral globules across different age groups. Six lesions (a-f) in patients aged 22 to 78 years, including melanoma in situ and invasive melanomas (Breslow 0.3-0.8 mm), illustrating the role of globule symmetry, size and color variability, associated central structures, and patient-level melanoma risk. - Supplementary Figure 3: Sequential handheld dermoscopic images at baseline, 3 and 6 months of a lesion in a 55-year-old patient with irregular peripheral globules and central asymmetry; excision revealed invasive melanoma (Breslow 0.5 mm). - Supplementary Figure 4: Sequential handheld dermoscopic images at baseline, 3 and 6 months of a lesion in a 22-year-old woman with a family history of melanoma, showing rapid growth and a chaotic dermoscopic pattern; excision revealed invasive melanoma (Breslow 0.45 mm). - Supplementary Table 1: Comparison of lesion-level characteristics between excised and non-excised lesions. - Supplementary Table 2: Secondary analysis restricted to the 143 excised lesions, showing melanoma-specific dermoscopic structures and other independent predictors of adverse histopathologic outcome.本数据集为论文《伴外周球状结构（peripheral globules）的黑素性皮损风险适应性监测：黑素瘤风险分层的纵向队列研究》（发表于《美国皮肤病学会杂志》，稿件编号JAAD-D-26-01408）的补充材料，作者为Kaan Gündüz, MD; Handan Merve Erol Mart, MD; Ömer Faruk Şimşek, MD; İlay Özsan, MD; Murat Doğuş Günel, MSc; Ayşe Öktem, MD; Bengü Nisa Akay, MD。根据该期刊的出版政策，补充材料未随论文一同刊发，而是单独托管于此。 本数据集包含以下内容： - 补充方法（Supplementary Methods）：完整的建模细节，涵盖先验设定、收敛诊断及模型拟合评估指标。 - 补充结果（Supplementary Results）：模型收敛性、患者层面异质性及样本外预测性能的详细分析结果。 - 补充图1（Supplementary Figure 1）：经组织病理学确认的伴外周球状结构（peripheral globules）的良性黑素细胞痣。共6处皮损（a-f），因出现记录到的形态变化、年龄相关风险提示、外周球状结构生长或持续存在，或在数字化监测期间触发临床警示而被活检或切除；所有皮损的组织病理学结果均为良性。 - 补充图2（Supplementary Figure 2）：经组织病理学确认的不同年龄组伴外周球状结构（peripheral globules）的黑素瘤。共6处皮损（a-f），患者年龄介于22至78岁，包括原位黑素瘤及侵袭性黑素瘤（Breslow厚度0.3~0.8 mm），展示了球状结构对称性、大小与颜色变异、伴随的中央结构特征以及患者层面黑素瘤风险的关联情况。 - 补充图3（Supplementary Figure 3）：1例55岁患者皮损的连续手持皮肤镜图像，分别采集于基线、3个月及6个月随访节点，该皮损伴不规则外周球状结构及中央不对称；术后病理证实为侵袭性黑素瘤（Breslow厚度0.5 mm）。 - 补充图4（Supplementary Figure 4）：1例22岁有黑素瘤家族史女性患者皮损的连续手持皮肤镜图像，分别采集于基线、3个月及6个月随访节点，该皮损表现为快速生长及紊乱的皮肤镜模式；术后病理证实为侵袭性黑素瘤（Breslow厚度0.45 mm）。 - 补充表1（Supplementary Table 1）：切除与未切除皮损的皮损层面特征对比分析。 - 补充表2（Supplementary Table 2）：针对143处切除皮损的二次分析，展示了黑素瘤特异性皮肤镜结构及其他不良组织病理学结局的独立预测因子。