Proinflammatory pattern of angiogenetic factors, chemokines and cytokines observed in the serum but not in the renal tissue of CD73−/−mice.

The levels of IL1-β, IL-2, IL-12p40, IL-15, IL-17, IFN-γ, GM-CSF, G-CSF, IL-13, MCP-1, interleukins 3, 4, 5, 10, 12p70, 13, M-CSF, MIG and RANTES were screened in the serum and renal tissue of CD73−/− and WT mice using BioPlex analysis. The serum levels of most measured cytokines and chemokines were slightly but not significantly elevated in the mutants as compared to the wild type controls, suggesting a proinflammatory pattern. The renal tissue levels were unaltered or even reduced in the CD73−/−mice compared to WT.