Targeting Csnk1a1 induces selective p53-dependant killing of leukemia stem cells

ChEBI2014-02-23 更新2026-07-21 收录

白血病靶向治疗

p53通路药物机制

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-52928 数据链接链接失效反馈

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Targeting Csnk1a1 induces selective p53-dependant killing of leukemia stem cells

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2014-02-23

Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia

白血病靶向治疗

ATP（三磷酸腺苷）

The chromatin-associated AAA+ ATPases Tip48 and Tip49 are the core components of various complexes implicated in diverse nuclear events such as DNA repair and gene regulation. Although they are freque

NIAID Data Ecosystem60

HOXA9 is required for survival in human MLL rearranged acute leukemias

白血病靶向治疗

基因功能研究

Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique biological characteristics and often have an unfavorable prognosis. Gene expression analyses demonst

NIAID Data Ecosystem50

A potent and selective small-molecule degrader of ENL suppresses leukemia progression in vivo (ChIP-Seq)

白血病靶向治疗

蛋白降解靶向嵌合体

ENL, a stoichiometric component of the Super Elongation Complex (SEC) as well as the histone H3K79 methyltransferase DOT1L complex, is involved in the regulation of transcription elongation. Loss-of-f

NIAID Data Ecosystem30

Supplementary Table S2 from Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia

磷酸化蛋白质组学

白血病靶向治疗

Class I phosphotyrosine (pY) sites of the "Tyrosine Kinases" enriched either in T-ALL (ALL-8, ALL-31) and B-ALL (ALL-17, ALL-19)

Figshare2016-05-01 更新50

A novel regulatory mechanism of U2 spliceosome proteostasis that controls the transcriptome and therapy response in cancer [RNAseq_CUTLL1_shSF3B1.2]

癌症剪接调控

白血病靶向治疗

Aberrant splicing is an important cause of cancer, and the production of noncanonical, cancer-specific, mRNA transcripts associate with transformation. Studies have focused on characterizing the effec

NIAID Data Ecosystem30

Targeting Csnk1a1 induces selective p53-dependant killing of leukemia stem cells

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