Effect of CORM-2 on CLP-induced intestinal inflammation.

Typical images of H&E stained intestinal sections from sham (A), CLP (B) rats or CLP rats with CORM-2 (C) or iCORM-2 (D) treatment. Severe inflammation (ulceration, hemorrhage and epithelial loss) was found in CLP rat (B) and CLP rats treated with iCORM (D). These changes were alleviated CLP rats treated with CORM-2 (C). These differences were semi-quantified using Chiu score system of mucosal injury by 2 investigators (E). Data are shown as means±SD. aP<0.05, compare to Sham rats; bP<0.05, compare to CLP rats; cP<0.05, compare to CLP rats treated with iCORM-2. Bar = 200μm.