Transcriptome-wide RNA and genome-wide DNA G-Quadruplex mediates alternative transcripts

We demonstrate that G4-DNA and G4-RNA may present splicing sites and alternative transcription starting positions on a transcriptome-wide and genome-wide scale by showing widespread effect on alternative transcripts in response to the established intracellular G4 binding ligands PDS. Examination of transcripts following PDS treatment in HCT116 and rat NP cells.